Mengapa memilih Jepang
Sourced from Nationwide (production hubs in Osaka, Kyoto, Oita) with year-round Japanese supply, consistent quality, and traceability to the prefecture of origin.
Spesifikasi utama
Serine protease from Bacillus subtilis var. natto source; FFC notification(s) on file; MOQ from 100 g – 10 kg (concentrated powder).
Produk akhir tipikal
Cardiovascular-positioned supplements (capsules) — Smooth blood flow under FFC where notified.
Sekilas
- Pemasok terdaftar
- 2 pemasok
- MOQ tipikal
- 100 g – 10 kg (bubuk terkonsentrasi)
- Waktu tunggu tipikal
- 4-6 minggu
- Daerah asal
- Nationwide (production hubs in Osaka, Kyoto, Oita)
- Kategori
- Bahan makanan
- Kisaran harga
- 140,000-180,000 JPY/kg
- Status regulasi Jepang
- Diterima FFC untuk kelancaran aliran darah
- Nama Jepang
- ナットウキナーゼ
- Romaji
- Natto Kinase
Tentang bahan ini
Enzim fibrinolitik yang ditemukan pada tahun 1980 oleh Dr. Hiroyuki Sumi, berasal dari fermentasi kedelai Bacillus subtilis natto.
Status regulasi
| Jepang | Diterima FFC untuk kelancaran aliran darah |
|---|---|
| Uni Eropa | Suplemen pangan; penilaian Novel Food dapat berlaku |
| Amerika Serikat | Suplemen makanan di bawah DSHEA |
FAQ untuk pembeli OEM
Q. What MOQ is typical for high-activity nattokinase concentrate?
Typical MOQs range from 100 g (for R&D) to 10 kg (production), with bulk lots available on request.
Sumber
- Source dossier (provided)
Klaim pengetahuan industri — belum disandarkan pada satu sumber primer
Q. What activity level is required for the JNKA mark?
JNKA-certified products require at least 2,000 FU per recommended daily dose, alongside vitamin K2 removal and other quality criteria.
Q. Why is vitamin K2 removed from many commercial preparations?
Vitamin K2 removal addresses formulation compatibility with consumers on warfarin-type anticoagulants, which interact with vitamin K. Suppliers offer K2-reduced grades; clinical precaution remains advised.
Q. Can nattokinase be sold as a dietary supplement in the US?
Nattokinase is sold in the US dietary supplement channel under DSHEA. Manufacturers and importers remain responsible for safety substantiation and labeling compliance.
Q. What documents should buyers request from a Japanese nattokinase supplier?
Standard requests include: COA with FU activity, JNKA certification status, vitamin K2 content, allergen statement (soy), GMO/non-GMO statement on substrate, and fermentation strain documentation.
Sumber
- Source dossier (provided)
Klaim pengetahuan industri — belum disandarkan pada satu sumber primer
Contoh penggunaan
Cardiovascular-positioned supplements (capsules)
- Positioning
- Smooth blood flow under FFC where notified
- Tingkat pemakaian tipikal
- ≥2,000 FU per daily dose for JNKA-certified products
- Catatan formulasi
- Enteric coating common; protect from heat and humidity
FFC functional foods
- Positioning
- Smooth blood flow positioning
- Catatan formulasi
- Endpoint wording must mirror individual FFC notification
Export supplements (US/EU/Asia)
- Positioning
- Cardiovascular wellness — non-disease, non-drug claims only
- Catatan formulasi
- Verify EU novel-food status of the specific extract; localize labeling
Sumber
Pemasok Jepang
Japan Bio Science Laboratory Co., Ltd.
株式会社日本生物.科学研究所
Pionir produksi komersial nattokinase sejak 1998. Pangsa pasar terdepan di Jepang (No. 1 menurut riset Fuji Keizai 2011). Produk unggulan NSK-SD (20.000 FU/g) dan NSK-FD (13.000 FU/g) dengan teknologi penghilangan Vitamin K2 yang dipatenkan. Metode IBox milik sendiri untuk identifikasi enzimatik.
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Pharma Foods International Co., Ltd.
株式会社ファーマフーズ
Pemimpin pasar global GABA hasil fermentasi alami. Pangsa pasar Jepang 80%. Merek PharmaGABA®. Perusahaan terbuka. Portofolio pangan fungsional luas termasuk nattokinase, GABA, lactoferrin.
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