Cosmetics · Quasi-drug actives
Dipotassium Glycyrrhizate
グリチルリチン酸2K (Guricchirurichin-san 2 K)
Also known as: Glycyrrhizinate Dipotassium
At a glance
| Category | Cosmetics |
|---|---|
| INCI name | Dipotassium Glycyrrhizate |
| Japanese labeling name | グリチルリチン酸2K |
| Common Japanese notations | グリチルリチン酸2K, グリチルリチン酸ジカリウム |
| CAS number | 68797-35-3 |
| Origin | Plant-derived (Glycyrrhiza root, processed to dipotassium salt) |
| Typical functions | Quasi-drug anti-inflammatory active |
| Regulatory status in Japan | Approved as a quasi-drug (医薬部外品) anti-inflammatory active by MHLW. Permitted across multiple product category claims. |
Dipotassium glycyrrhizate is the water-soluble dipotassium salt of glycyrrhizic acid, the major glycoside from licorice (Glycyrrhiza) root. It is one of the most-used quasi-drug anti-inflammatory active ingredients in Japan, appearing across medicated skincare, oral care, and bath products.
Classification
Tags below link to other ingredients sharing the same attribute, so you can pivot from one ingredient to its peers.
Product applications
Functions
Regulatory tags
Origin
Used in (typical product categories)
Finished-product categories that commonly include this ingredient in Japanese-market formulations.
- Medicated sensitive-skin lines
- Medicated acne products (薬用ニキビケア)
- Quasi-drug oral care
- Quasi-drug bath products
What it is
Dipotassium glycyrrhizate is produced by salt exchange from glycyrrhizic acid extracted from Glycyrrhiza root. The water-soluble dipotassium form is preferred for aqueous cosmetic formulations.
Typical uses in Japanese products
In Japanese cosmetics, dipotassium glycyrrhizate appears in sensitive-skin lines, anti-acne products, sunscreens marketed for sensitive skin, oral care, and bath products.
Regulatory classification in Japan
Approved as a quasi-drug anti-inflammatory active by MHLW.
Regulatory classification in other markets
| EU | Listed in CosIng. Permitted for cosmetic use. |
|---|---|
| USA | INCI recognized. |
| China | Permitted per IECIC listings. |
| Korea | Permitted under KFDA / MFDS. |
Example products
Example finished products will be added after each product's current full ingredient list has been verified.
All brand names and product names referenced anywhere on this site are the property of their respective owners. Example entries are provided for informational purposes only and do not imply endorsement.
Related ingredients
References
- Japan PMDA — quasi-drug active ingredient approval registry
- EU CosIng entry: Dipotassium Glycyrrhizate
Last updated: 2026-04-22. Ingredient entries are reviewed at least annually against current regulatory listings.