Supplements · Amino acids & peptides
Lactotripeptide
ラクトトリペプチド (Rakutotori peputido)
Also known as: Val-Pro-Pro / Ile-Pro-Pro tripeptides from milk casein
Looking for a Japanese supplier of Lactotripeptide? Tell usAt a glance
| Category | Supplements |
|---|---|
| INCI name | Not applicable (food use)↗ |
| Japanese labeling name | Not applicable (food use) |
| Common Japanese notations | ラクトトリペプチド |
| Origin | Animal-derived (peptides from enzymatic hydrolysis of milk casein) |
| Typical functions | FFC active for blood pressure support |
| Regulatory status in Japan | Lactotripeptide-containing products are recognized under Japan's Foods for Specified Health Uses (Tokuho, 特定保健用食品) for blood pressure support — the original Tokuho approval (Calpis Co.'s Ameal S series) dates to 1997. Newer reformulations have also been notified under the Foods with Function Claims (機能性表示食品) system. |
Lactotripeptide refers to a small set of bioactive tripeptides — primarily Val-Pro-Pro and Ile-Pro-Pro — produced by enzymatic hydrolysis of milk casein. In Japan it is one of the established functional ingredients used in beverages and supplements positioning around blood pressure support.
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Classification
Tags below link to other ingredients sharing the same attribute, so you can pivot from one ingredient to its peers.
Common OEM product categories
Finished-product categories where Japanese OEM manufacturers commonly formulate with this ingredient.
- Yogurt-style functional drinks
- FFC supplements
- Functional beverages
Ingredient profile
Lactotripeptide products typically contain the tripeptides Val-Pro-Pro and Ile-Pro-Pro, produced by specific protease cleavage of casein.
OEM applications
In Japan, lactotripeptide is the active functional ingredient in several yogurt-style functional beverages and supplements.
Regulatory classification in Japan
FFC notifications involving lactotripeptide are on file with the Consumer Affairs Agency.
Regulatory classification in other markets
| EU | Use as a functional food ingredient may require Novel Food evaluation; specific health claims require EFSA review. |
|---|---|
| USA | Sold as a dietary supplement ingredient. |
| China | Verify against current authority listings. |
| Korea | Permitted. |
Market reference formulations
Example finished products will be added after verification.
All brand names and product names referenced anywhere on this site are the property of their respective owners. Example entries are provided for informational purposes only and do not imply endorsement.
Typical OEM use levels
Formulation ranges per finished-product application. Verify against the cited source before production.
| Application | Typical range | Regulatory limit | Notes |
|---|---|---|---|
| Functional Food (FFC) — blood-pressure claim (Japan) | Daily intake 3.4 mg of Val-Pro-Pro / Ile-Pro-Pro per FFC notifications | Per consumer-affairs notification; published in 機能性表示食品DB | 消費者庁 機能性表示食品データベース |
Storage requirements
How the receiving OEM facility needs to handle inbound raw material.
- Temperature
- Refrigerated 4°C for activity; spray-dried form room temperature
- Conditions
- Sealed against moisture
- Shelf life
- 24 months sealed
Supply concentration
Where this ingredient comes from — useful for single-source-risk planning.
- Primary regions
- Calpis (Asahi Group) historical innovator; production in Japan
- Import dependence
- Mostly domestic; commodity Val-Pro-Pro / Ile-Pro-Pro available globally
Asahi Group references
Alternative ingredients
Related ingredients commonly evaluated as substitutes.
Quick answers
- What is Lactotripeptide?
- Lactotripeptide refers to a small set of bioactive tripeptides — primarily Val-Pro-Pro and Ile-Pro-Pro — produced by enzymatic hydrolysis of milk casein. In Japan it is one of the established functional ingredients used in beverages and supplements positioning around blood pressure support.
- What is the regulatory status of Lactotripeptide in Japan?
- Lactotripeptide-containing products are recognized under Japan's Foods for Specified Health Uses (Tokuho, 特定保健用食品) for blood pressure support — the original Tokuho approval (Calpis Co.'s Ameal S series) dates to 1997. Newer reformulations have also been notified under the Foods with Function Claims (機能性表示食品) system.
- What products typically use Lactotripeptide?
- Yogurt-style functional drinks / FFC supplements / Functional beverages
- Where does Lactotripeptide come from?
- Animal-derived (peptides from enzymatic hydrolysis of milk casein)
- What is the INCI / JSCI labeling name for Lactotripeptide?
- INCI: Not applicable (food use) / JSCI: Not applicable (food use)
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Sharing similar functions
Ingredients that overlap on functional benefit tags.
From the same origin
Other ingredients that share an origin classification.
Regulatory guidance
Take the next step
FAQ for OEM buyers
Q. What are the specific lactotripeptide sequences and their origin?
The two main milk-derived lactotripeptides used in Japanese functional foods are Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), produced by Lactobacillus helveticus fermentation of milk casein. Calpis (Asahi Group) holds historical IP around the production process for FFC/FOSHU applications.
Sources · Last reviewed: 2026-04-26
Q. What is the regulatory status for blood-pressure claims in Japan?
Lactotripeptides have FOSHU (Tokuho) approval for 'helping maintain healthy blood pressure for those with mildly elevated blood pressure' as well as multiple FFC notifications. Buyers must follow the exact approved claim language and dose for each product.
Sources · Last reviewed: 2026-04-26
Q. What is the typical functional daily dose?
FOSHU/FFC blood pressure products typically deliver 3.4 mg of VPP+IPP combined per day, often in a single 100-200 mL drink or tablet serving. Dose must match the specific notification.
Sources · Last reviewed: 2026-04-26
Q. Are there milk-allergen labeling considerations?
Yes — because lactotripeptide is derived from milk casein, all products containing it must declare 'milk' as an allergen under Japan's mandatory allergen labeling regulations (and equivalent rules in EU/US). This applies even to highly purified peptide preparations.
Sources · Last reviewed: 2026-04-26
Use cases
Blood-pressure FOSHU yogurt drink (PET, 100-200 mL)
- Positioning
- Daily blood pressure support for mildly elevated consumers
- Typical usage level
- 3.4 mg VPP+IPP per bottle
- Formulation notes
- Cultured milk drink base; refrigerated chain distribution.
FOSHU/FFC tablet supplement
- Positioning
- Shelf-stable daily blood pressure support
- Typical usage level
- 3.4 mg per daily dose (tablets)
- Formulation notes
- Powder/tablet formulation with milk-allergen declaration on label.
Functional dairy yogurt cup
- Positioning
- Cultured dairy with blood pressure positioning
- Formulation notes
- Cup yogurt format; cold-chain distribution.
Sources
- Industry knowledge — Japanese functional dairy market
Industry-knowledge claim — not yet pinned to a single primary source
Search the academic literature
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Official regulatory databases
External links to public Japanese / international regulatory authorities. We are not affiliated.
References
- Japan Consumer Affairs Agency — Foods with Function Claims notification database
Last updated: 2026-04-22. Ingredient entries are reviewed at least annually against current regulatory listings.