Supplements · Amino acids & peptides
Lactotripeptide
ラクトトリペプチド (Rakutotori peputido)
Also known as: Val-Pro-Pro / Ile-Pro-Pro tripeptides from milk casein
At a glance
| Category | Supplements |
|---|---|
| INCI name | Not applicable (food use) |
| Japanese labeling name | Not applicable (food use) |
| Common Japanese notations | ラクトトリペプチド |
| Origin | Animal-derived (peptides from enzymatic hydrolysis of milk casein) |
| Typical functions | FFC active for blood pressure support |
| Regulatory status in Japan | Lactotripeptide-containing products are recognized under Japan's Foods for Specified Health Uses (Tokuho, 特定保健用食品) for blood pressure support — the original Tokuho approval (Calpis Co.'s Ameal S series) dates to 1997. Newer reformulations have also been notified under the Foods with Function Claims (機能性表示食品) system. |
Lactotripeptide refers to a small set of bioactive tripeptides — primarily Val-Pro-Pro and Ile-Pro-Pro — produced by enzymatic hydrolysis of milk casein. In Japan it is one of the established functional ingredients used in beverages and supplements positioning around blood pressure support.
Classification
Tags below link to other ingredients sharing the same attribute, so you can pivot from one ingredient to its peers.
Used in (typical product categories)
Finished-product categories that commonly include this ingredient in Japanese-market formulations.
- Yogurt-style functional drinks
- FFC supplements
- Functional beverages
What it is
Lactotripeptide products typically contain the tripeptides Val-Pro-Pro and Ile-Pro-Pro, produced by specific protease cleavage of casein.
Typical uses in Japanese products
In Japan, lactotripeptide is the active functional ingredient in several yogurt-style functional beverages and supplements.
Regulatory classification in Japan
FFC notifications involving lactotripeptide are on file with the Consumer Affairs Agency.
Regulatory classification in other markets
| EU | Use as a functional food ingredient may require Novel Food evaluation; specific health claims require EFSA review. |
|---|---|
| USA | Sold as a dietary supplement ingredient. |
| China | Verify against current authority listings. |
| Korea | Permitted. |
Example products
Example finished products will be added after verification.
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Related ingredients
References
- Japan Consumer Affairs Agency — Foods with Function Claims notification database
Last updated: 2026-04-22. Ingredient entries are reviewed at least annually against current regulatory listings.