Medicinal plants
Japanese traditional medicinal plants with kampo heritage and K-Beauty demand — yomogi, dokudami, related botanicals.
31 ingredients in this category.
About this category
Japanese medicinal plants — covering the kampo (traditional Japanese herbal medicine) materia medica and a parallel folk-medicine tradition known as minkan-yaku — represent one of the most regulated and clinically integrated herbal supply categories in the developed world. Unlike most herbal markets, kampo formulations are reimbursed under Japan's national health insurance (over 148 formulas and 240+ crude drugs are listed), giving the supply chain pharmaceutical-grade rigor. Folk medicines such as yomogi (Artemisia princeps), dokudami (Houttuynia cordata), biwa (loquat) leaf, kakidoshi (Glechoma hederacea var. grandis), and gennoshoko (Geranium thunbergii) are sold both as dietary teas and as quasi-drug remedies. Combined exports of Japanese medicinal plant raw materials and standardized extracts are estimated at USD 200–280 million annually (industry estimate, 2024–2026), with growth concentrated in Europe (where kampo is gaining traction in integrative medicine clinics) and Greater China (where Japanese-grown crude drugs command a premium over domestic equivalents).
The heritage of Japanese medicinal plants is built on a 1,500-year transmission of Chinese materia medica, progressively adapted to Japanese flora and clinical philosophy. The Heian-period Ishinpō (984 CE) is the oldest surviving Japanese medical text and already lists many herbs still in modern kampo formulations. The Edo-period Koho-ha movement led by Yoshimasu Todo systematized formula-based prescribing in the 18th century, creating the framework still used today. Western medicine displaced kampo during the Meiji modernization, but the practice was rehabilitated in the 1970s when the Ministry of Health began approving kampo formulations for insurance reimbursement. Folk-medicine herbs developed in parallel: yomogi was used both as a culinary herb (kusa-mochi) and in moxibustion; dokudami earned its name 'poison-blocking' for its reputed detoxifying properties; biwa leaf has been used since Buddhist temple medicine traditions arrived in Japan.
The contemporary supplier base is dominated by Tsumura (the global leader in pharmaceutical kampo, holding over 80% of Japanese hospital kampo market share), Kracie Pharma (consumer-facing kampo and quasi-drug formulations), Kotaro Pharmaceutical, Honzo, and a network of crude drug houses including Uchida Wakanyaku, Tochimoto Tenkaido, and Matsuura Yakugyo. These suppliers operate Japanese GMP for pharmaceutical-grade extracts and supply both whole herbs and standardized hot-water extract powders. For folk-medicine and tea-channel supply, regional cooperatives in Kyushu (yomogi, dokudami), Tohoku (kakidoshi, gennoshoko), and Wakayama (biwa) lead production, with most holding JAS Organic and FSSC 22000 certification for export-oriented lines.
For overseas buyers, Japanese medicinal plants offer an unusually well-documented supply chain: each lot typically comes with botanical authentication (often DNA-verified for high-value species), heavy metal and pesticide residue COAs, microbial counts to Japanese Pharmacopoeia 18 standards, and (for kampo-grade material) full chromatographic fingerprinting against Japanese Pharmacopoeia reference standards. MOQs vary: pharmaceutical-grade standardized extracts often start at 50–100 kg, while crude herbs for tea-channel buyers can be sourced from 10 kg lots. Buyers should clarify intended end-use (food vs supplement vs cosmetic vs registered herbal medicine) early in the conversation, as documentation requirements diverge significantly between channels and lead times can stretch from 6 weeks for tea-channel material to 6 months for pharmaceutical kampo extract.
To explore the catalogue, begin with our Medicinal Plants sourcing list, then filter by kampo-grade, organic-certified, or folk-medicine tea-channel material. Related categories include Food Ingredients (for tea-channel and culinary herbs such as shiso, mitsuba, and yomogi), Beverage Ingredients (for kampo-derived functional teas and infusions), and Cosmetic Raw Materials (for kampo botanical extracts increasingly used in skincare). The Supplements glossary provides definitions of standardized extract specifications, marker compound assays, and FFC-relevant evidence frameworks for buyers building functional supplement formulas.
Key facts
- Market position
- Japanese medicinal plant exports total an estimated USD 200–280 million annually (industry estimate, 2024–2026); Tsumura holds over 80% of the Japanese pharmaceutical kampo market and is the world's largest GMP-certified kampo manufacturer.
- Heritage
- Kampo materia medica derives from Chinese sources transmitted from the 6th century onward; the Ishinpō (984 CE) is Japan's oldest surviving medical text; modern reimbursement-listed kampo includes 148+ formulations.
- Differentiation vs Korean / Chinese competitors
- Japanese-grown crude drugs offer Japanese Pharmacopoeia 18 quality standards, pharmaceutical GMP traceability, DNA-authenticated botanicals, and chromatographic fingerprinting that exceeds Chinese GAP/GMP and Korean KGMP requirements; this provenance commands a 30–80% price premium.
- Certifications
- Japanese GMP for pharmaceutical kampo, JAS Organic, FSSC 22000, ISO 9001, GACP (Good Agricultural and Collection Practice for medicinal plants), Halal certification for selected lines, EU GMP-equivalence for export-grade materials.
- Notable ingredients
- Yomogi (Artemisia princeps), dokudami (Houttuynia cordata), biwa (loquat) leaf, gennoshoko (Geranium thunbergii), kakidoshi (Glechoma hederacea), kanzo (licorice), shakuyaku (peony root), tochuso (Eucommia ulmoides), and Japanese-grown ginseng (Panax ginseng, oto-ne).
Where to start
Editor's picks for first-time visitors to this category.
Regulatory at a glance
Medicinal plants occupy an unusually wide regulatory spectrum in Japan. Pharmaceutical-grade kampo formulations are governed by the PMD Act and require manufacturing site GMP licensing. Quasi-drug herbal preparations sit in a middle tier with PMD Act registration but lighter clinical requirements. Tea-channel and culinary herbs are governed by the Food Sanitation Act, with FFC available for actives with sufficient evidence. For exports, the destination-market classification typically determines pathway: an herb shipped as 'kampo extract' for European clinical use may need a Traditional Herbal Medicinal Product (THMP) registration under EU Directive 2004/24/EC, requiring 30 years of documented traditional use (15 in the EU). US buyers should verify FDA dietary supplement classification under DSHEA and check whether the ingredient is on FDA's 'old dietary ingredient' list (pre-1994) — many Japanese herbs require an NDIN. Key safety considerations for buyers: glycyrrhizin from kanzo (licorice) has a recognized aldosterone-mimetic effect and is dose-restricted in EU food supplements; shakuyaku and other Aristolochia-family botanicals have been the subject of nephrotoxicity concerns in adjacent Chinese herbs (Japanese kampo does not use Aristolochia, but buyers should verify supplier botanical sourcing); and several wild-harvested species fall under CITES — buyers should request CITES screening for any wild-harvested input. Heavy metal limits under Japanese Pharmacopoeia are stricter than US Pharmacopeia for several elements (cadmium, arsenic), giving Japanese-sourced herbs a quality advantage in tightly regulated EU markets.
All ingredients in Medicinal plants
- GlossaryRaw material6 suppliers
Shiso / Perilla Frutescens Leaf Extract
紫蘇葉エキス
Perilla frutescens, known in Japan as shiso (紫蘇), is a herb of the mint family used in Japanese cooking and traditional medicine. The leaves contain rosmarinic acid, perillaldehyde, and anthocyanins (in the red variety). Used in cosmetics for soothing and antioxidant positioning.
Aichi (green/red shiso), Tottori +1MOQ 10–30 kg - GlossaryRaw material3 suppliers
Kuromoji / Lindera Umbellata
黒文字
Kuromoji (Lindera umbellata) is a deciduous shrub in the Lauraceae family, native to Honshu, Shikoku, and Kyushu mountain forests. Traditionally used for tea-ceremony toothpicks and premium wagashi picks. Steam-distilled essential oil offers a fresh, citrusy-woody profile with major components linalool, 1,8-cineole, α/β-pinene. Positions as a uniquely Japanese alternative to hinoki with satoyama sustainability credentials.
Gifu, Nagano +4MOQ 100 ml – 1 L essential oil; 1–10 kg dried - GlossaryRaw material4 suppliers
Green Papaya
青パパイヤ
Unripe papaya harvested before ripening, rich in papain, chymopapain, and carpain enzymes. Japanese fermentation techniques enable safe supplement use (raw papain is pharmaceutical-designated).
Okinawa Prefecture (primary), KagoshimaMOQ 1–50 kg (powder); 100 g – 10 kg (fermented extract) - GlossaryRaw material3 suppliers
Botanboufu (Sakuna)
ボタンボウフウ
Hardy perennial herb (Apiaceae family) native to Yonaguni Island and other subtropical Ryukyu coastlines. A local Okinawan longevity herb with chlorogenic acid and rutin content comparable to or exceeding kale.
Yonaguni Island (Okinawa), Amami Islands +1MOQ 1-100 kg (powder); 500 g – 10 kg (extract) - GlossaryRaw material5 suppliers
Japanese Jujube
日本産ナツメ
Premium domestic Japanese jujube, primarily cultivated in Fukui Prefecture's Natsume district. Kampo medicine grade Taisō (大棗) variety dominates, pesticide-free and traceable.
Fukui (Natsume district), Nara +1MOQ 100 g – 10 kg (dried); 100 g – 1 kg (extract) - GlossaryRaw material3 suppliers
Japanese Reishi Mushroom
日本産霊芝
Domestic Japanese reishi mushroom, including rare rokkaku reishi (deer-antler form with 50%+ β-glucan content). Japanese cultivation technology pioneered in the 1970s. Sakamoto Bio (Akita), Ōkō (Hokkaido, organic JAS), and Jōyaku Kenkyūsho are primary Japanese producers.
Akita, Hokkaido (Mibai) +1MOQ 100 g – 10 kg - GlossaryActive component2 suppliers
Maitake D-Fraction Extract
舞茸 D-フラクション
Standardised beta-1,6-glucan extract from maitake mushroom (Grifola frondosa), originally developed at the Kobe Pharmaceutical University in the 1980s. Niigata is the primary cultivation region (~70% of Japan's maitake by volume). The D-fraction is positioned in immune-support and adjuvant supplement contexts internationally; clinical literature exists for both dietary and oncology-adjuvant settings. Functional foods featuring D-fraction must clear country-specific regulatory pathways (FFC in Japan, NDI in US, etc.).
Niigata (~70%), Yamagata +2MOQ 1–10 kg powder extract; 100 g – 1 kg standardised actives - GlossaryActive component2 suppliers
Shiitake Mycelium Extract
シイタケ菌糸体エキス
Hot-water extract of cultured shiitake mycelium, distinct from the fruiting body in active-ingredient profile. Japanese R&D has standardised lentinan and LEM (Lentinula Edodes Mycelium extract) preparations since the 1980s for immune-support positioning. Major industrial producers in Mie, Gifu, and Niigata supply both supplement and functional-food markets, with substantial export to North American and European immune-positioned supplement brands. Distinct from shiitake-fruiting-body extracts (which are part of the existing 'shiitake-functional' trend coverage).
Mie, Gifu +1MOQ 1–10 kg powder; 100 g – 1 kg standardised LEM - GlossaryActive component3 suppliers
Reishi (Mannentake / Lingzhi)
霊芝 / 万年茸
A foundational TCM/Kampo medicinal mushroom (Ganoderma lucidum). Japanese cultivation, primarily in Nagano and Niigata, evolved beyond traditional wild collection into standardised indoor cultivation in the 1970s. Modern Japanese reishi suppliers produce both fruiting-body and spore (hoshi) extracts, with the spore variant carrying premium pricing on the back of triterpene concentration. FFC notifications support immune-support positioning domestically. Substantial export to North American supplement and functional-coffee categories.
Nagano, Niigata +1MOQ 1–10 kg powder; 100 g – 1 kg spore extract - GlossaryActive component2 suppliers
Sasa Bamboo Leaf Extract
クマザサエキス
Extract of kumazasa (dwarf bamboo) leaves, primarily Sasa veitchii and S. kurilensis from Japanese mountain regions. Used historically as a natural preservative for ekiben (railway lunchboxes) and traditional confectionery on the back of antibacterial polysaccharide content. Modern functional positioning leverages alkaline polysaccharide and chlorophyll-derived actives for both cosmetic (deodorising / antibacterial) and food-supplement (digestive / antioxidant) applications. Hokkaido and Nagano are the principal commercial harvest regions.
Hokkaido, Nagano +2MOQ 10–50 kg dried leaf; 1–10 kg extract - GlossaryRaw material3 suppliers
Ashitaba (Tomorrow's Leaf)
アシタバ / 明日葉
Native Japanese herb (Angelica keiskei), endemic to the Izu Islands and the Pacific coast of Honshu. Named 'tomorrow's leaf' for its rapid regrowth (a new leaf typically appears the day after harvest). Functional profile centres on chalcone compounds (xanthoangelol, 4-hydroxyderricin) studied for cardiovascular and anti-inflammatory positioning. Hachijojima (Izu Islands), Tokyo's volcanic islands, has GI-protected status for ashitaba; Yakushima and the Boso Peninsula also produce. Used in supplements, functional teas, and increasingly cosmetic active-ingredient lines.
Tokyo (Izu Islands — Hachijojima, Niijima), Chiba (Boso Peninsula) +1MOQ 10–50 kg dried; 1–10 kg standardised extract - GlossaryRaw material3 suppliers
Hatomugi (Job's Tears) Extract
ハトムギエキス
Traditional Japanese grain (Coix lacryma-jobi var. ma-yuen) consumed for centuries as hatomugi-cha and as a Kampo herbal raw material (Yokuinin). Functional positioning centres on coixenolide and coixol active fractions for skin-positioned beauty applications, plus the seed's protein and dietary fibre profile for general nutrition. Tochigi, Tottori, Saitama, and Toyama host the principal cultivation. Cosmetic ingredient grades drive premium skincare lines — especially in 'mochi-hada' (mochi-skin) positioning — while hatomugi-cha remains a major retail beverage category.
Tochigi, Tottori +2MOQ 10–50 kg seed; 1–10 kg extract - GlossaryRaw material1 supplier
Biwa (Japanese Loquat)
枇杷
Japanese loquat (Eriobotrya japonica) — Nagasaki and Chiba produce the principal commercial fruit supply; the leaves have substantial Kampo herbal use. Distinguished from imported loquat by superior fresh-fruit eating quality. Cosmetic-grade biwa-leaf extract (existing glossary slug 'eriobotrya-japonica-leaf-extract') anchors anti-inflammatory and skin-calming positioning. Distinct from existing food / herbal entries.
Nagasaki (largest fresh), Chiba +1MOQ 10–50 kg fresh; 1–10 kg leaf extract
FAQ: sourcing medicinal plants from Japan
Q. Are Japanese medicinal plants (kampo botanicals) regulated as foods or drugs?
Most Japanese medicinal plants in this catalog (yomogi, dokudami, kuko-no-mi) are food-classified when sold as teas, extracts, or supplements without medical claims. They become OTC/prescription drugs only when used in registered kampo formulations or with medical claims. Buyers should verify final-product claim positioning for their target market.
Sources
- MHLW — List of substances classified as drugs (専ら医薬品)
- Japanese Pharmacopoeia 18th Edition — kampo crude drugs
Q. What's the difference between Japanese (wakanyaku) and Chinese (zhongyao) medicinal herbs?
Many shared species exist between Japanese kampo and Chinese TCM, but Japanese cultivation often emphasizes lower pesticide load, cleaner growing regions (e.g., Hokkaido, Iwate), and stricter curing standards. Japanese-grown crude drugs typically command 2–5x the price of Chinese-imported equivalents.
Sources
- Industry knowledge — Japanese vs Chinese herbal supply chain
Industry-knowledge claim — not yet pinned to a single primary source
Q. Are Japanese medicinal plants compliant with US dietary supplement and EU food/herbal standards?
Most are compliant when used with appropriate claim restrictions. EU Novel Food status should be checked for less common species (e.g., specific kampo crude drugs not common in Europe). US DSHEA generally accommodates traditional Japanese herbs with documented use history. China NMPA has separate approval pathways for medicinal plants used in cosmetics or supplements.
Sources
- EU Novel Food Catalogue
- FDA — DSHEA dietary supplements
Q. What's the typical MOQ for Japanese medicinal plant extracts?
Standard kampo crude drugs (dried whole or sliced) ship in 5–10 kg minimums. Concentrated extracts (5x–20x) typically start at 1–5 kg. Premium organic-certified or GAP-grown materials may have higher minimums and longer lead times (8–12 weeks).
Sources
- Industry knowledge — Japanese kampo and herbal supply
Industry-knowledge claim — not yet pinned to a single primary source