Cosmetics · Quasi-drug actives
Trans-3,4'-Dimethyl-3-Hydroxyflavanone
トランス-3,4'-ジメチル-3-ヒドロキシフラバノン (Toransu jimechiru hidorokishi furabanon)
Also known as: Kao markets a preparation as t-Flavanone
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| Category | Cosmetics |
|---|---|
| INCI name | Flavanone derivative (specification-dependent)↗ |
| Japanese labeling name | トランス-3,4'-ジメチル-3-ヒドロキシフラバノン |
| Common Japanese notations | トランス-3,4'-ジメチル-3-ヒドロキシフラバノン, t-フラバノン |
| Origin | Synthetic (flavanone derivative) |
| Typical functions | Quasi-drug hair growth / scalp active |
| Regulatory status in Japan | Approved as a quasi-drug (医薬部外品) active by Japan's 厚生労働省 (Ministry of Health, Labour and Welfare). Approval applied for by Kao Corporation. |
Trans-3,4'-dimethyl-3-hydroxyflavanone is a synthetic flavanone derivative developed by Kao Corporation as a quasi-drug active for hair-related claims. Kao markets its preparation of this ingredient under the brand name t-Flavanone.
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Classification
Tags below link to other ingredients sharing the same attribute, so you can pivot from one ingredient to its peers.
Product applications
Functions
Regulatory tags
Origin
Common OEM product categories
Finished-product categories where Japanese OEM manufacturers commonly formulate with this ingredient.
- Medicated hair tonics (薬用育毛剤)
- Scalp-care products marketed by Kao
Ingredient profile
Trans-3,4'-dimethyl-3-hydroxyflavanone is a flavanone-class compound with specific methyl and hydroxyl substituents. It is a developed-for-hair-care active that functions through pathways related to hair follicle activity.
OEM applications
Use is concentrated in Kao's medicated hair tonics and scalp-care products.
Regulatory classification in Japan
Approved by 厚生労働省 (Ministry of Health, Labour and Welfare) as a quasi-drug hair active following Kao Corporation's application. Permitted claims relate to scalp / hair function within the standard quasi-drug claim framework.
Regulatory classification in other markets
| EU | Verify the specific INCI registration in current CosIng. |
|---|---|
| USA | Verify INCI registration. |
| China | Verify against current IECIC listings. |
| Korea | Verify against current KFDA / MFDS listings. |
Market reference formulations
Use is concentrated in Kao's medicated hair-care lines. Specific SKU listings will be added after each product's current full ingredient list has been verified.
All brand names and product names referenced anywhere on this site are the property of their respective owners. Example entries are provided for informational purposes only and do not imply endorsement.
Typical OEM use levels
Formulation ranges per finished-product application. Verify against the cited source before production.
| Application | Typical range | Regulatory limit | Notes |
|---|---|---|---|
| Quasi-drug hair-growth tonic / scalp lotion (Japan) | 0.3% (representative) | Set per individual 厚生労働省 quasi-drug notification | Marketed by Shiseido as t-flavanone; licensed to selected hair-care brands(厚生労働省 医薬部外品有効成分通知) |
Stability & compatibility
- pH range
- pH 4–7
- Temperature
- Stable at standard cosmetic processing temperatures
- Incompatibilities
- Strong oxidizers
- Highly alkaline systems
Synthetic flavanone derivative; pre-dissolve in ethanol or propylene glycol for hair-tonic bases.
Alternative ingredients
Related ingredients commonly evaluated as substitutes.
Quick answers
- What is Trans-3,4'-Dimethyl-3-Hydroxyflavanone?
- Trans-3,4'-dimethyl-3-hydroxyflavanone is a synthetic flavanone derivative developed by Kao Corporation as a quasi-drug active for hair-related claims. Kao markets its preparation of this ingredient under the brand name t-Flavanone.
- What is the regulatory status of Trans-3,4'-Dimethyl-3-Hydroxyflavanone in Japan?
- Approved as a quasi-drug (医薬部外品) active by Japan's 厚生労働省 (Ministry of Health, Labour and Welfare). Approval applied for by Kao Corporation.
- What products typically use Trans-3,4'-Dimethyl-3-Hydroxyflavanone?
- Medicated hair tonics (薬用育毛剤) / Scalp-care products marketed by Kao
- Where does Trans-3,4'-Dimethyl-3-Hydroxyflavanone come from?
- Synthetic (flavanone derivative)
- What is the INCI / JSCI labeling name for Trans-3,4'-Dimethyl-3-Hydroxyflavanone?
- INCI: Flavanone derivative (specification-dependent) / JSCI: トランス-3,4'-ジメチル-3-ヒドロキシフラバノン
Explore related ingredients
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From the same origin
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Regulatory guidance
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FAQ for OEM buyers
Q. What is this flavanone derivative used for in Japanese cosmetics?
Trans-3,4'-dimethyl-3-hydroxyflavanone (t-Flavanone) is a Kao-developed scalp/hair active used in medicated hair-tonic products positioned for prevention of hair loss and scalp care.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — Kao Success/Care medicated hair-tonic line
Industry-knowledge claim — not yet pinned to a single primary source
Q. Is it on Japan's quasi-drug active ingredient list?
Yes — it is a Kao-developed quasi-drug active for medicated hair-tonic and scalp-care products approved by 厚生労働省 (Ministry of Health, Labour and Welfare); finished products must be filed as quasi-drugs.
Sources · Last reviewed: 2026-04-26
- 厚生労働省 (Ministry of Health, Labour and Welfare) — quasi-drug approval lists (medicated hair-tonic actives)
Q. Can third-party OEMs source this ingredient?
Commercial supply has been confined to Kao's own product lines (e.g., Success); the molecule is Kao-proprietary and not generally available to third-party OEMs.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — Kao proprietary actives
Industry-knowledge claim — not yet pinned to a single primary source
Q. What product formats use this active?
Primarily alcoholic hair-tonic sprays and scalp essences within Kao's Success and adjacent medicated hair-care brands.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — Kao Success line
Industry-knowledge claim — not yet pinned to a single primary source
Use cases
Medicated hair tonic (薬用育毛トニック)
- Positioning
- Men's scalp-care, hair-thinning prevention
- Formulation notes
- Alcohol-based spray format; combined with other Kao scalp actives such as menthol.
Sources
- Industry knowledge — Kao Success product range
Industry-knowledge claim — not yet pinned to a single primary source
Scalp essence
- Positioning
- Daily-use scalp wellness within medicated hair-care line
- Formulation notes
- Leave-on scalp serum format; quasi-drug filing required for hair-loss claims.
Sources
- Industry knowledge — Japanese medicated scalp-care category
Industry-knowledge claim — not yet pinned to a single primary source
Medicated unisex hair-care kit
- Positioning
- Combined shampoo + tonic regimen
- Formulation notes
- Active concentrated in tonic component; not typically formulated into rinse-off shampoo.
Sources
- Industry knowledge — Japanese medicated hair-care bundles
Industry-knowledge claim — not yet pinned to a single primary source
Search the academic literature
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Official regulatory databases
External links to public Japanese / international regulatory authorities. We are not affiliated.
References
- Japan 医薬品医療機器総合機構 PMDA (Pharmaceuticals and Medical Devices Agency) — quasi-drug active ingredient approval registry
- Kao Corporation technical publications referencing t-Flavanone
Last updated: 2026-04-22. Ingredient entries are reviewed at least annually against current regulatory listings.