Cosmetics · Quasi-drug actives
Dipotassium Glycyrrhizate
グリチルリチン酸2K (Guricchirurichin-san 2 K)
Also known as: Glycyrrhizinate Dipotassium
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| Category | Cosmetics |
|---|---|
| INCI name | Dipotassium Glycyrrhizate↗ |
| Japanese labeling name | グリチルリチン酸2K |
| Common Japanese notations | グリチルリチン酸2K, グリチルリチン酸ジカリウム |
| CAS number | 68797-35-3↗ |
| Origin | Plant-derived (Glycyrrhiza root, processed to dipotassium salt) |
| Typical functions | Quasi-drug anti-inflammatory active |
| Regulatory status in Japan | Approved as a quasi-drug (医薬部外品) anti-inflammatory active by 厚生労働省 (Ministry of Health, Labour and Welfare). Permitted across multiple product category claims. |
Dipotassium glycyrrhizate is the water-soluble dipotassium salt of glycyrrhizic acid, the major glycoside from licorice (Glycyrrhiza) root. It is one of the most-used quasi-drug anti-inflammatory active ingredients in Japan, appearing across medicated skincare, oral care, and bath products.
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Classification
Tags below link to other ingredients sharing the same attribute, so you can pivot from one ingredient to its peers.
Product applications
Functions
Regulatory tags
Common OEM product categories
Finished-product categories where Japanese OEM manufacturers commonly formulate with this ingredient.
- Medicated sensitive-skin lines
- Medicated acne products (薬用ニキビケア)
- Quasi-drug oral care
- Quasi-drug bath products
Ingredient profile
Dipotassium glycyrrhizate is produced by salt exchange from glycyrrhizic acid extracted from Glycyrrhiza root. The water-soluble dipotassium form is preferred for aqueous cosmetic formulations.
OEM applications
In Japanese cosmetics, dipotassium glycyrrhizate appears in sensitive-skin lines, anti-acne products, sunscreens marketed for sensitive skin, oral care, and bath products.
Regulatory classification in Japan
Approved as a quasi-drug anti-inflammatory active by 厚生労働省 (Ministry of Health, Labour and Welfare).
Regulatory classification in other markets
| EU | Listed in CosIng. Permitted for cosmetic use. |
|---|---|
| USA | INCI recognized. |
| China | Permitted per IECIC listings. |
| Korea | Permitted under KFDA / MFDS. |
Market reference formulations
Example finished products will be added after each product's current full ingredient list has been verified.
All brand names and product names referenced anywhere on this site are the property of their respective owners. Example entries are provided for informational purposes only and do not imply endorsement.
Typical OEM use levels
Formulation ranges per finished-product application. Verify against the cited source before production.
| Application | Typical range | Regulatory limit | Notes |
|---|---|---|---|
| Quasi-drug anti-inflammatory skin / oral / scalp products (Japan) | 0.05–0.2% | Capped per 厚生労働省 quasi-drug notification per product | Approved as 抗炎症 active in 医薬部外品(厚生労働省 医薬部外品有効成分通知) |
Stability & compatibility
- pH range
- pH 5.0–9.0 (broadly stable)
- Temperature
- Highly stable; tolerates standard hot- and cold-process formulation
- Incompatibilities
- Strong acids (dipotassium salt may precipitate at low pH)
Water-soluble dipotassium salt of glycyrrhizic acid; one of the most formulation-friendly anti-inflammatory actives in Japanese cosmetics.
Alternative ingredients
Related ingredients commonly evaluated as substitutes.
Quick answers
- What is Dipotassium Glycyrrhizate?
- Dipotassium glycyrrhizate is the water-soluble dipotassium salt of glycyrrhizic acid, the major glycoside from licorice (Glycyrrhiza) root. It is one of the most-used quasi-drug anti-inflammatory active ingredients in Japan, appearing across medicated skincare, oral care, and bath products.
- What is the regulatory status of Dipotassium Glycyrrhizate in Japan?
- Approved as a quasi-drug (医薬部外品) anti-inflammatory active by 厚生労働省 (Ministry of Health, Labour and Welfare). Permitted across multiple product category claims.
- What products typically use Dipotassium Glycyrrhizate?
- Medicated sensitive-skin lines / Medicated acne products (薬用ニキビケア) / Quasi-drug oral care / Quasi-drug bath products
- Where does Dipotassium Glycyrrhizate come from?
- Plant-derived (Glycyrrhiza root, processed to dipotassium salt)
- What is the INCI / JSCI labeling name for Dipotassium Glycyrrhizate?
- INCI: Dipotassium Glycyrrhizate / JSCI: グリチルリチン酸2K
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From the same origin
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Regulatory guidance
Take the next step
FAQ for OEM buyers
Q. Is dipotassium glycyrrhizate approved as a quasi-drug active in Japan?
Yes — it is on the 厚生労働省 (Ministry of Health, Labour and Welfare) quasi-drug active ingredient list as an anti-inflammatory active (抗炎症) used in medicated acne, sensitive-skin, oral care, and bath products. Quasi-drug claims around skin irritation and acne require quasi-drug notification.
Sources · Last reviewed: 2026-04-26
- 厚生労働省 (Ministry of Health, Labour and Welfare) — quasi-drug anti-inflammatory actives (dipotassium glycyrrhizate)
Q. What is the typical use level and pH compatibility?
Used at 0.05–0.5% in cosmetic anti-inflammatory positioning and up to ~0.3% in medicated quasi-drugs; freely water-soluble and stable across pH 5–8. Above pH 8 or with certain cationic surfactants, precipitation can occur.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — dipotassium glycyrrhizate formulation practice
Industry-knowledge claim — not yet pinned to a single primary source
Q. What is the source of the ingredient?
It is the dipotassium salt of glycyrrhizic acid extracted from licorice (Glycyrrhiza glabra/uralensis) root. Buyers commonly request a non-GMO and pesticide-residue spec at qualification.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — licorice extract sourcing
Industry-knowledge claim — not yet pinned to a single primary source
Q. Are there export restrictions or allergen concerns?
There are no major regulatory restrictions in Japan, EU, US, or China; dipotassium glycyrrhizate is on China's IECIC inventory and is broadly accepted. Allergen disclosure is not required.
Sources · Last reviewed: 2026-04-26
- China NMPA — IECIC inventory
Use cases
Medicated acne lotion (薬用ニキビケア化粧水)
- Positioning
- Anti-inflammatory acne care quasi-drug
- Typical usage level
- 0.1–0.3% (Japan quasi-drug)
- Formulation notes
- Combined with salicylic acid or IPMP; pH 5–7 water phase.
Sources
- Industry knowledge — Japanese medicated acne segment
Industry-knowledge claim — not yet pinned to a single primary source
Sensitive-skin moisturizer
- Positioning
- Daily-use sensitive-skin lotion / cream
- Typical usage level
- 0.05–0.2%
- Formulation notes
- Combined with ceramides, panthenol, and allantoin for soothing claims.
Sources
- Industry knowledge — sensitive-skin formulation
Industry-knowledge claim — not yet pinned to a single primary source
Oral care (medicated toothpaste / mouthwash)
- Positioning
- Anti-inflammatory gum-care quasi-drug
- Formulation notes
- Used at 0.05–0.2% in toothpaste and mouthwash; quasi-drug filing for gum-inflammation claims.
Sources
- Industry knowledge — Japanese medicated oral-care category
Industry-knowledge claim — not yet pinned to a single primary source
Sensitive-skin sunscreen
- Positioning
- Sensitive-skin / baby-friendly sunscreen
- Formulation notes
- Used at 0.05–0.2% in mineral sunscreen base; combined with allantoin.
Sources
- Industry knowledge — sensitive-skin sunscreen formulation
Industry-knowledge claim — not yet pinned to a single primary source
Medicated bath additive
- Positioning
- Soothing bath-tablet / bath salt for sensitive skin
- Formulation notes
- Water-soluble; combined with sodium bicarbonate and other bath actives.
Sources
- Industry knowledge — Japanese medicated bath-additive segment
Industry-knowledge claim — not yet pinned to a single primary source
Search the academic literature
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Official regulatory databases
External links to public Japanese / international regulatory authorities. We are not affiliated.
References
- Japan 医薬品医療機器総合機構 PMDA (Pharmaceuticals and Medical Devices Agency) — quasi-drug active ingredient approval registry
- EU CosIng entry: Dipotassium Glycyrrhizate
Last updated: 2026-04-22. Ingredient entries are reviewed at least annually against current regulatory listings.