Supplements · Marine functional
Salmon Nasal Cartilage-Derived Proteoglycan
サケ鼻軟骨由来プロテオグリカン (Sake hana-nankotsu yurai puroteogurikan)
Also known as: Salmon Cartilage Proteoglycan, Hirosaki Proteoglycan
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| Category | Supplements |
|---|---|
| INCI name | Proteoglycan (specification-dependent)↗ |
| Japanese labeling name | プロテオグリカン (preparation-specific) |
| Common Japanese notations | サケ鼻軟骨由来プロテオグリカン, プロテオグリカン |
| Origin | Animal-derived (extracted from salmon nasal cartilage) |
| Typical functions | Joint function support (supplement context), Skin moisture support, Cosmetic skin conditioning |
| Regulatory status in Japan | Functional food applications notified under Foods with Function Claims (機能性表示食品). Cosmetic use under JSCI dictionary. |
Salmon nasal cartilage-derived proteoglycan is a Japanese functional ingredient with industry-academia origins. Cost-effective extraction of proteoglycan from salmon byproducts (specifically nasal cartilage) was developed through collaboration centered around Hirosaki University in Aomori prefecture, with regional Aomori companies contributing to commercial-scale production.
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Classification
Tags below link to other ingredients sharing the same attribute, so you can pivot from one ingredient to its peers.
Common OEM product categories
Finished-product categories where Japanese OEM manufacturers commonly formulate with this ingredient.
- Joint-care supplements (FFC notifications)
- Skin-moisture functional supplements
- Moisturizing essences
- Sheet masks
Ingredient profile
Proteoglycan is a class of glycoprotein consisting of a core protein with covalently attached glycosaminoglycan chains. The salmon-nasal-cartilage-derived preparation specifically extracts intact proteoglycan molecules from a marine byproduct that was historically discarded.
Commercial-scale extraction methods developed through Aomori-based industry-academia collaboration substantially reduced production cost compared to earlier purification routes, enabling the ingredient's expansion into supplement and cosmetic categories.
OEM applications
In supplements, salmon-derived proteoglycan is used in joint-function and skin-moisture positioning. Specific FFC notifications exist for some brand-claim combinations; verify in the Consumer Affairs Agency database.
In cosmetics, proteoglycan preparations appear in moisturizing essences, sheet masks, and serums.
Regulatory classification in Japan
Functional food uses are notified case-by-case under the Foods with Function Claims system.
Cosmetic use is permitted under JSCI dictionary preparation-specific entries.
Regulatory classification in other markets
| EU | Marine-derived proteoglycan supplement uses may fall under Novel Food regulation depending on the specific preparation. Cosmetic uses should be verified in CosIng. |
|---|---|
| USA | Marine proteoglycan supplements are sold. |
| China | Cosmetic and supplement uses should be verified against current authority listings. |
| Korea | Verify against current KFDA / MFDS listings. |
Market reference formulations
Example finished products are marketed by various Japanese brands, with significant industry presence centered in Aomori-based suppliers.
All brand names and product names referenced anywhere on this site are the property of their respective owners. Example entries are provided for informational purposes only and do not imply endorsement.
Alternative ingredients
Related ingredients commonly evaluated as substitutes.
Quick answers
- What is Salmon Nasal Cartilage-Derived Proteoglycan?
- Salmon nasal cartilage-derived proteoglycan is a Japanese functional ingredient with industry-academia origins. Cost-effective extraction of proteoglycan from salmon byproducts (specifically nasal cartilage) was developed through collaboration centered around Hirosaki University in Aomori prefecture, with regional Aomori companies contributing to commercial-scale production.
- What is the regulatory status of Salmon Nasal Cartilage-Derived Proteoglycan in Japan?
- Functional food applications notified under Foods with Function Claims (機能性表示食品). Cosmetic use under JSCI dictionary.
- What products typically use Salmon Nasal Cartilage-Derived Proteoglycan?
- Joint-care supplements (FFC notifications) / Skin-moisture functional supplements / Moisturizing essences / Sheet masks
- Where does Salmon Nasal Cartilage-Derived Proteoglycan come from?
- Animal-derived (extracted from salmon nasal cartilage)
- What is the INCI / JSCI labeling name for Salmon Nasal Cartilage-Derived Proteoglycan?
- INCI: Proteoglycan (specification-dependent) / JSCI: プロテオグリカン (preparation-specific)
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From the same origin
Other ingredients that share an origin classification.
Regulatory guidance
Take the next step
FAQ for OEM buyers
Q. What is the IP/origin story of salmon nasal cartilage proteoglycan?
The high-yield extraction process for proteoglycan from salmon nasal cartilage was developed at Hirosaki University (Aomori, Japan) in the 2000s, and is licensed/produced through partner suppliers using Aomori-landed salmon as the raw material. This 'Aomori salmon proteoglycan' origin story is a key positioning element.
Sources · Last reviewed: 2026-04-26
- Hirosaki University — Proteoglycan research and licensing program (Industry knowledge)
Q. Are there approved Foods with Function Claims (FFC) products containing salmon proteoglycan?
Yes — multiple FFC notifications using salmon-derived proteoglycan exist for joint comfort and skin moisture-related claims. Buyers must verify the exact functional ingredient name, dose, and claim language against each notification in the Consumer Affairs Agency database.
Sources · Last reviewed: 2026-04-26
Q. What are typical daily doses for proteoglycan supplements?
FFC-notified salmon proteoglycan supplements typically use daily doses in the range of 5-10 mg of proteoglycan, depending on the specific notification and target claim. Capsule, tablet, and powder formats are all in market.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — Japanese proteoglycan supplement market
Industry-knowledge claim — not yet pinned to a single primary source
Q. What are typical MOQs and pricing tier for proteoglycan as an OEM ingredient?
Salmon proteoglycan is a premium-priced ingredient (often several JPY per mg of active), so OEM quotes commonly use kg-level minimums and finished-product MOQs of 10,000-30,000 capsules. Suppliers typically require an end-product label review before shipping.
Sources · Last reviewed: 2026-04-26
- Industry knowledge — Japanese functional ingredient supply
Industry-knowledge claim — not yet pinned to a single primary source
Use cases
Joint-comfort supplement capsule (FFC-notified)
- Positioning
- Joint-flexibility daily supplement targeting active seniors
- Typical usage level
- 5-10 mg proteoglycan per daily dose
- Formulation notes
- Often combined with type II collagen or hyaluronic acid in same SKU.
Skin-moisture-positioned beauty drink
- Positioning
- Inner beauty RTD with collagen + proteoglycan
- Formulation notes
- 50-100 mL glass or PET bottle; often combined with hyaluronic acid, vitamin C.
Sources
- Industry knowledge — Japanese inner beauty drink market
Industry-knowledge claim — not yet pinned to a single primary source
High-end moisturizing essence (cosmetic)
- Positioning
- Premium age-care line emphasizing salmon-PG ingredient story
- Typical usage level
- 0.01-0.5% in formula
- Formulation notes
- Heat-sensitive — added in cooling phase of emulsion manufacture.
Sources
- Industry knowledge — Japanese premium cosmetic formulation
Industry-knowledge claim — not yet pinned to a single primary source
Sheet mask premium SKU
- Positioning
- Single-use intensive moisture treatment
- Typical usage level
- 0.01-0.1%
- Formulation notes
- Combined with HA, glycerin in serum essence.
Sources
- Industry knowledge — Japanese sheet mask formulation
Industry-knowledge claim — not yet pinned to a single primary source
Search the academic literature
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Official regulatory databases
External links to public Japanese / international regulatory authorities. We are not affiliated.
References
- Hirosaki University — Salmon proteoglycan industry-academia collaboration publications
- Japan Consumer Affairs Agency — Foods with Function Claims notification database
Last updated: 2026-04-22. Ingredient entries are reviewed at least annually against current regulatory listings.